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Listar por autor "García Domínguez, Irene"  

Mostrando ítems 1-16 de 16

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      ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain 

      Stratoulias, Vassilis; Ruiz Laza, Agustín; Kanatani, Shigeaki; Osman, Ahmed Mohamed; Keane, Lily; Armengol, Jose A.; García Domínguez, Irene; Alonso Bellido, Isabel María; Venero Recio, José Luis; Joseph, Bertrand (Nature Research, 2023)
      Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ...
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      Beta-Cyanoalanine synthase action in root hair elongation is exerted at early steps of the root hair elongation pathway and is independent of direct cyanide inactivation of NADPH oxidase 

      Arenas Alfonseca, Lucía; Gotor Martínez, Cecilia; Romero González, Luis Carlos; García Domínguez, Irene (Oxford University Press, 2018)
      In Arabidopsis thaliana, cyanide is produced concomitantly with ethylene biosynthesis and is mainly detoxified by the ...
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      Beyond toxicity: A regulatory role for mitochondrial cyanide 

      García Domínguez, Irene; Gotor Martínez, Cecilia; Romero González, Luis Carlos (Landes Bioscience, 2014)
      In non-cyanogenic plants, cyanide is a co-product of ethylene and camalexin biosynthesis. To maintain cyanide at non-toxic ...
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      Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease 

      Tayara, Khadija; Espinosa Oliva, Ana María; García Domínguez, Irene; Ismaiel, Afrah Abdul; Boza Serrano, Antonio; Deierborg, Tomas; Martínez de Pablos, Rocío; Machado de la Quintana, Alberto; Herrera Carmona, Antonio José; Venero Recio, José Luis (Frontiers Media, 2018)
      The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ...
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      Evaluating the cancer therapeutic potential of cardiac glycosides 

      Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Maldonado Navas, Dolores; García Domínguez, Irene; López Lázaro, Miguel (Hindawi Publishing Corporation, 2014)
      Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ...
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      Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia 

      Fernández Martín, Juan Carlos; Espinosa Oliva, Ana María; García Domínguez, Irene; Rosado Sánchez, Isaac; Pacheco, Yolanda María; Moyano, Rosario; Monterde, José G.; Venero Recio, José Luis; Martínez de Pablos, Rocío (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
      Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ...
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      Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon 

      Espinosa Oliva, Ana María; García Miranda, Pablo; Alonso Bellido, Isabel María; Carvajal Vázquez, Ana Eloisa; González Rodríguez, Melania; Carrillo Jiménez, Alejandro; García Domínguez, Irene; Vázquez Carretero, María Dolores; García Revilla, Juan; Santiago Pavón, Martiniano; Peral Rubio, María José; Venero Recio, José Luis; Martínez de Pablos, Rocío (Frontiers Media, 2021)
      Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ...
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      Geminivirus C2 protein represses genes involved in sulphur assimilation and this effect can be counteracted by jasmonate treatment 

      Lozano Durán, Rosa; García Domínguez, Irene; Huguet, Stéphanie; Balzergue, Sandrine; Romero González, Luis Carlos; Bejarano, Eduardo R. (Springer, 2012)
      Geminiviruses are plant viruses that infect a broad range of crops and cause extensive losses worldwide, having an important ...
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      HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System 

      Bachiller, Sara; Roca Ceballos, María Angustias; García Domínguez, Irene; Pérez Villegas, Eva María; Martos Carmona, David; Pérez Castro, Miguel Ángel; Real Navarrete, Luis Miguel; Rosa, José Luis; Tabares, Lucía; Venero Recio, José Luis; Armengol, José Ángel; Carrión, Ángel Manuel; Ruiz Laza, Rocío (Springer, 2018-03-30)
      A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
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      Implicación de las caspasas-3 y -8 en el trastorno del espectro autista y la enfermedad de Parkinson 

      García Domínguez, Irene (2020-03-06)
      El trastorno del espectro autista (TEA) y la enfermedad de Parkinson (EP) son dos desórdenes neurológicos que presentan ...
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      Inhibition of Arabidopsis O-acetylserine (Thiol)lyase A1 by tyrosine-nitration 

      Álvarez Núñez, Consolación; Lozano Juste, Jorge; Romero González, Luis Carlos; García Domínguez, Irene; Gotor Martínez, Cecilia; León, José (American Society for Biochemistry and Molecular Biology, 2011)
      The last step of sulfur assimilation is catalyzed by O-acetylserine(thiol)lyase (OASTL) enzymes. OASTLs are encoded by a ...
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      Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease 

      García Domínguez, Irene; Veselá, Karolina; García Revilla, Juan; Carrillo Jiménez, Alejandro; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Venero Recio, José Luis (Frontiers Media, 2018)
      The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ...
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      Reformulating Pro-Oxidant Microglia in Neurodegeneration 

      García Revilla, Juan; Alonso Bellido, Isabel María; Burguillos García, Miguel Ángel; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Ruiz Laza, Rocío; Cruz Hernández, Luis; García Domínguez, Irene; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Rodríguez Gómez, José Antonio; Sarmiento Soto, Manuel; Martínez de Pablos, Rocío; Venero Recio, José Luis (MDPI, 2019)
      In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ...
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      Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour 

      García Domínguez, Irene; Suárez Pereira, Irene; Santiago Pavón, Martiniano; Pérez Villegas, Eva M.; Bravo, Lidia; López Martín, Carolina; Roca Ceballos, María Angustias; García Revilla, Juan; Espinosa Oliva, Ana María; Rodríguez Gómez, José Antonio; Joseph, Bertrand; Berrocoso, Esther; Armengol, José Ángel; Venero Recio, José Luis; Ruiz Laza, Rocío; Martínez de Pablos, Rocío (Elsevier, 2021-01-10)
      Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ...
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      TET2 Regulates the Neuroinflammatory Response in Microglia 

      Carrillo Jiménez, Alejandro; Ruiz Laza, Rocío; García Domínguez, Irene; García Revilla, Juan; Espinosa Oliva, Ana María; Venero Recio, José Luis; Burguillos García, Miguel Ángel; Tayara, Khadija (Elsevier, 2019)
      Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ...
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      The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior 

      Suárez Pereira, Irene; García Domínguez, Irene; Bravo, L.; Santiago Pavón, Martiniano; García Revilla, Juan; Espinosa Oliva, Ana María; Alonso Bellido, Isabel María; López Martín, César; Pérez Villegas, Eva María; Armengol, J. A.; Berrocoso, E.; Venero Recio, José Luis; Martínez de Pablos, Rocío; Ruiz Laza, Rocío (Frontiers Media S.A., 2022)
      In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ...